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  • Paxil (Paroxetine)

    Anyone taking Paxil (Paroxetine)?

    I've been prescribed Paxil CR, mainly for my OCD and anxiety-related symptoms. It's only been a week, so I haven't noticed much of a change, except for side-effects. Makes me a bit sleepy, and I feel a bit sick at certain times of the day, but I'm trying to power through this stage while my body gets used to it.

    Anyone had any noteworthy experiences with Paxil?
    Colin

  • #2
    Paxil (Paroxetine)

    Caileen,

    I have not taken paxil but I was seriously considering a medication for anxiety. Have you noticed anything with improvement to your anxiety? Have you noticed anything with how it interacts or affects with TS? ( I would take something for my OCD but I think that may be the only reason my house is always clean, lol)
    The other day at a local grocery store, I saw a rack with books on it and one of them said, "pregancy for dummies"............

    Comment


    • #3
      Paxil (Paroxetine)

      Paxil (paroxitine) is marketed in Canada by Glaxo Smith Kline. A pdf of the Canadian Product Monograph is available HERE

      Another overview of the medication based on U.S. information, which is essentially the same as the information used in Canada is available HERE

      DRUG CLASS AND MECHANISM: Paroxetine is an anti-depressant drug that affects the chemicals that nerves in the brain use to communicate with one another. These chemical messengers, called neurotransmitters, are released by one nerve and taken up by other nerves. Neurotransmitters that are released but not taken up by other nerves are taken up by the nerves that release them ("reuptake"). Many experts believe that it is an imbalance among the amounts of the different neurotransmitters that are released that causes depression. Paroxetine works by inhibiting the reuptake of serotonin by the nerves that release it, an action which allows more serotonin to be available to be taken up by other nerves. Paroxetine is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs), a class that also contains fluoxetine (Prozac) and sertraline (Zoloft).

      SSRI's have been found to be useful in treating a number of disorders in addition to depression...like OCD, anxiety, social phobia, panic disorder as well as mood disorders associated with premenstrual tension.

      DRUG INTERACTIONS: All SSRIs, including paroxetine, should not be taken with any of the MAO (mono-amine oxidase) inhibitor-class of anti-depressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane). Such combinations may lead to confusion, high blood pressure, tremor, and increased activity. This same type of interaction may also occur with selegiline (Eldepryl), fenfluramine (Pondimin), and dexfenfluramine (Redux). The anti-ulcer medication, cimetidine (Tagamet) can increase the amount of paroxetine in the blood, possibly leading to side effects. Paroxetine may increase the risk of bleeding in patients taking warfarin (Coumadin) although the mechanism for the interaction is not known. Tryptophan can cause headaches, nausea, sweating, and dizziness when taken with any SSRI. Phenytoin (Dilantin) and phenobarbital may decrease the amount of paroxetine in the body and possibly reducing its effectiveness.

      Paxil interacts with a variety of medications, so before taking anything including over the counter meds like cough syrup containing dextromethorphan-promethazine or dextromethorphan-pseudoephedrine , check one of the online drug interaction sites. If you need a reference for one of these sites, let me know.

      Discontinuation of Paxil should be accomplished over a period of time while tapering the dose as opposed to sudden withdrawl.

      Nausea and somnolence (drowsiness) are common side effects associated with SSRI's because of their effect on neurotransmitters. However as the body becomes acclimated to the new medication, these side effects usually disappear.

      The therapeutic effect is not immediate and requires a few weeks to become noticeable. Communication with your physician is important during this time to report how well you are tolerating the medication.

      It is possible that when the dosage is increased, you will experience renewed side effects until your body becomes acclimated to the new dosage. However if you find the side effects don't go away after a week to ten days, get back to your doctor.

      Most important: do not suddenly stop Paxil once you've been taking it for a while, because of the potential for withdrawl symptoms. It must be tapered to avoid withdrawl.

      Most people taking Paxil tolerate it well and find it to be effective.
      Steve
      TouretteLinks Forum

      Comment


      • #4
        Paxil (Paroxetine)

        Steve,

        I took clonidine and orap for many years but I have been off both for about 8 or 9 months now. Do you know if either of these would interact bad with it? Obviously I will consult my doctor but if you know they dont mix well, than I dont wanna waste his time, lol, well, and owe him a billion dollars for just a visit.
        The other day at a local grocery store, I saw a rack with books on it and one of them said, "pregancy for dummies"............

        Comment


        • #5
          Paxil (Paroxetine)

          Adam,

          Health Canada posted a warning against using Paxil and Orap.

          Click Here for info.

          If you come across a similar warning from the FDA, would you let us know?

          You can search for drug interactions at the Discovery Health Interaction Checker.

          In order for the Interaction Checker to work, you need to temporarily disable your Pop Up Blocker while on their site.

          Use the Alphabetical index to identify the various medications for which you are checking interactions...check off the med then click on Check interactions.

          You will be provided with drug/drug and drug/food interactions for the combination of meds you entered.
          Steve
          TouretteLinks Forum

          Comment


          • #6
            Paxil (Paroxetine)

            Originally posted by Adam
            I have not taken paxil but I was seriously considering a medication for anxiety. Have you noticed anything with improvement to your anxiety? Have you noticed anything with how it interacts or affects with TS? ( I would take something for my OCD but I think that may be the only reason my house is always clean, lol)
            No, I haven't been taking it long enough. It's only my sixth day today, so all I have so far are a few side effects (headaches, light-headedness), which I'm told will go away.

            I was told it could take 2-3 weeks for anxiety/OCD symptoms to be affected. (It takes even longer to help depression, but I don't have that problem).
            Colin

            Comment


            • #7
              Paxil (Paroxetine)

              Originally posted by Steve
              Most important: do not suddenly stop Paxil once you've been taking it for a while, because of the potential for withdrawl symptoms. It must be tapered to avoid withdrawl.
              Yeah, if you read the pamphlet that comes with Paxil CR, it lists the withdrawl symptoms. One of them is "electic shock sensations". That's... strange.
              Colin

              Comment


              • #8
                Paxil (Paroxetine)

                Altering brain chemistry requires professional skills, which is why communication with one's physician s so important.

                If Paxil is tapered when discontinuing therapy, there should be little or no withdrawl....the listed effects are all the reported adverse effects by all participants in their study. Does not mean everyone experienced all the effects and to the same degree.

                Paxil is generally well tolerated. However in people who do not tolerate on particular SSRI, switching to another one sometimes succeeds.
                Steve
                TouretteLinks Forum

                Comment


                • #9
                  Paxil (Paroxetine)

                  Steve,

                  I know when watching the paxil commercial they mention a number of drugs that should not be used with it but I will check if orap is one. Now, again I have been off of it for almost a year and at this rate I may stay off of it, I had better results from clonidine.
                  The other day at a local grocery store, I saw a rack with books on it and one of them said, "pregancy for dummies"............

                  Comment


                  • #10
                    Paxil (Paroxetine)

                    Update:

                    After a month so far, Paxil does not appear to be working.
                    Colin

                    Comment


                    • #11
                      Paxil (Paroxetine)

                      What's the dose you are taking? What does your doctor suggest..switching to another SSRI?
                      Steve
                      TouretteLinks Forum

                      Comment


                      • #12
                        Paxil (Paroxetine)

                        I'm only on 25 mg. I have an appt on Friday so I'm giving it until then until I talk to him. He may suggest a higher dose.
                        Colin

                        Comment


                        • #13
                          Paxil (Paroxetine)

                          Let us know the outcome of your visit.

                          Paxil CR, according to the product monograph reaches steady state in about two weeks, when the dosage becomes stabilized in the body.

                          Discuss with your doctor in how long you should expect to notice any change in the way you feel.

                          If discontinuation is recommended, or switching to another SSRI or other medication, be sure to get specific instructions on whether you require a "wash-out" period from the Paxil-CR before beginning the new med and if the Paxil-CR needs to be tapered off...gradually withdrawn while reducing the dose.

                          This information is very important to avoid any adverse reactions when discontinuing or changing meds.
                          Steve
                          TouretteLinks Forum

                          Comment


                          • #14
                            Paxil (Paroxetine)

                            So for the past few weeks my OCD has gone out of control... I've been panic-stricken, paranoid, etc.

                            Went to see the doctor on Friday. He believes the Paxil was actually to blame -- that I'm one of the rare cases in which Paxil actually aggravates the condition.

                            He's told me to stop immediately. (Normally you do need to gradually reduce Paxil in your system, but I was on a fairly low dose for a relatively short period of time, so the risk of withdrawl symptoms is low.)
                            Colin

                            Comment


                            • #15
                              Paxil (Paroxetine)

                              Has the doctor substituted the Paxil with another SSRI?

                              The prescribing information of Paxil CR and Paxil recommend tapering, so if you experience withdrawl symptoms like nausea, sleeplessness or unusual stimulation, contact your doctor and discuss the possibility of tapering the dose over a week or so.

                              Paroxetine (Paxil) has a short metabolic half life, which results in a rapid steady state when therapy is initiated, but results in withdrawl if medication is withdrawn abruptly...therefore tapering is recommended by the manufacturer.
                              Steve
                              TouretteLinks Forum

                              Comment

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