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Familialty of TS, OCD, ADHD

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  • Familialty of TS, OCD, ADHD

    Familiality of Tourette Syndrome, Obsessive-Compulsive Disorder, and Attention-Deficit\Hyperactivity Disorder: Heritability Analysis in a Large Sib-Pair Sample
    Carol A. Mathews, M.D. and Marco A. Grados, M.D., M.P.H.

    J Am Acad Child Adolesc Psychiatry. Author manuscript; available in PMC 2012 Jan 1.
    Published in final edited form as:
    J Am Acad Child Adolesc Psychiatry. 2011 Jan; 50(1): 46–54.
    Published online 2010 Nov 18. doi: 10.1016/j.jaac.2010.10.004

    Abstract
    Objective

    Tourette Syndrome (TS) is a neuropsychiatric disorder with a genetic component that is highly comorbid with obsessive-compulsive disorder (OCD) and attention deficit/hyperactivity disorder (ADHD). However, the genetic relationships between these disorders have not been clearly elucidated. In this study we examine the familial relationships between TS, OCD, and ADHD in a large sample of TS families.

    Method
    Parent-offspring concordance of TS, OCD, and ADHD was examined in 952 individuals from 222 TS-affected sib pair families originally collected for genetic studies using logistic regression with generalized estimating equations (GEE) to control for correlated data. Variance components methods were used to estimate the heritability and genetic and environmental correlations between TS, OCD, and ADHD. Bilineal families where both parents had either TS or OCD were excluded.

    Results
    OCD and ADHD were highly heritable in these TS families. We found significant genetic correlations between TS and OCD and between OCD and ADHD, but not between TS and ADHD. We also found significant environmental correlations between TS and ADHD and between OCD and ADHD. Parental OCD+ADHD was associated with offspring OCD+ADHD.

    Conclusions
    This study provides further evidence for a genetic relationship between TS and OCD, and suggests that the observed relationship between TS and ADHD may in part be due to a genetic association between OCD and ADHD and in part due to shared environmental factors.



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