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Thread: Hereditary?

  1. #1

    Default Hereditary?

    Hi all,

    If TS is hereditary does that mean that others TS sufferers will show up in one's immediate or extended family? My son has not been diagnosed yet, but shows signs of TS that are described here. He definitely has more than one motor tic and breathing tic. Wouldn't there be evidence of these symptoms in other family members, both immediate and extended members?
    Do all of you TS sufferers have other family members with TS symptoms? Thanks.

    Grammy

  2. #2
    Join Date
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    Default Hereditary?

    Thanks to our Forum moderator, Stephanie for discovering this resource which I would like to share with you:

    What causes Tourette syndrome?

    Although the basic cause of Tourette syndrome is unknown, current research suggests that there is an abnormality in a gene (or genes) affecting the brain's metabolism of neurotransmitters such as dopamine, serotonin, and norepinephrine. Neurotransmitters are chemicals in the brain that carry signals from one nerve cell to another.

    Is Tourette syndrome inherited?

    Tourette syndrome is inherited as an autosomal dominant trait with incomplete penetrance and variable expression. What this means is as follows:

    Autosomal: The gene for Tourette syndrome is autosomal; it is on one of the autosomes (the non-sex chromosomes). A person, male or female, with the Tourette syndrome gene has a 50-50 chance of passing on the gene to each one of his or her offspring.

    Dominant: The gene for Tourette syndrome is capable of expressing itself in single copy. This means that the gene from one parent is sufficient to cause the syndrome.

    Incomplete penetrance: If a gene is completely penetrant in a population, everyone with the gene expresses it. However, not everyone with the Tourette syndrome gene has Tourette syndrome. The Tourette syndrome gene is thus incompletely penetrant.

    Variable expression: The gene for Tourette syndrome may express itself as a milder tic disorder, or as obsessive compulsive behaviors, or possibly as attention deficit disorder with few or no tics at all. A higher than normal incidence of milder tic disorders and obsessive compulsive behaviors has been found in families of individuals with Tourette syndrome.

    Although we have referred to "the" Tourette syndrome gene, please understand that there may be two or more genes responsible for Tourette syndrome.

    What is sporadic Tourette syndrome?

    In some cases of Tourette syndrome, inheritance cannot be determined. These cases are called sporadic and their cause is unknown.

    What is the role of gender in Tourette syndrome?

    Gender plays an important role in the expression of the Tourette syndrome gene. In a male with the Tourette syndrome gene, the risk of developing symptoms is 3 to 4 times higher than a female with the gene.

    Should all cases of Tourette syndrome be treated?

    No. Many cases of Tourette syndrome are so mild that they do not require treatment, and certainly not treatment with medications.

    Source

  3. #3

    Default Hereditary?

    Thanks Steve.

    So this is why, then, when people have success with meds or alternative treatments such as supplements, the symptoms return when treatment is stopped? TS is incurable at the present? For those whose symptoms subside partly or seemingly completely, does the underlying TS still remain? Thanks.

    Grammy

  4. #4
    Join Date
    Apr 2005
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    Ottawa, Canada
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    Default Hereditary?

    At present any medications which reduce Tourette symptoms are simply controlling symptoms.

    There is no cure for Tourette at present and the gene responsible for Tourette has not yet been isolated.

    Throughout one's lifetime Tourette symptoms wax and wane, a hallmark of Tourette and the repertoire of tics changes, while some tics remain lifelong.

    So you are correct, that for those whose symptoms subside, the disorder remains.

  5. #5
    Join Date
    Sep 2005
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    Georgia Chapter of the TSFC
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    Default Hereditary?

    Steve, I was not able to trace that source back to a specific doctor or research paper. Any help would be appreciated, oh Master of Sources (no sarcasm). I just can't stop myself from disagreeing...

    According to Dr. David Comings, TS+ is NOT autosomal dominant. It is polygenic, which means it is like skin color, having many switches that create a huge possibility of differing symptoms, which we have seen. And do not forget that there are a LOT of families where only one person has TS+. Dominant genes would not work like that.

    As for the 3 times as many boys thing, the number is essentially the same for OCD (alone) with girls. Hmmm... maybe that means society and culture have some impact on the way we act even within the TS+ disorders. Boys (in North America at least) are given much more room to be physical and athletic. Girls are still (the struggle continues) expected to be quieter and sit still and be more (ugh) domestic. Sounds like TS for boys and OCD for girls. Weird, huh, how the diagnoses play out just like the cultural expectation?

    And do not forget that we are ALWAYS talking about diagnosed TS+. How many people out there are suffering silently with OCD?[/u][/list]
    Darin M. Bush, The Tourette Tiger, author of "Tiger Trails"
    http://www.facebook.com/tourettetiger

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