Thanks Thanks:  0
Likes Likes:  0
Results 1 to 3 of 3

Thread: Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis

  1. #1
    Join Date
    Apr 2005
    Location
    Ottawa, Canada
    Posts
    5,941

    Post Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis

    Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis
    Nature.com
    March 5, 2015

    European Journal of Human Genetics , (4 March 2015) | doi:10.1038/ejhg.2015.22

    Christiaan de Leeuw, Andrea Goudriaan, August B Smit, Dongmei Yu, Carol A Mathews, Jeremiah M Scharf, Tourette Syndrome Association International Consortium for Genetics, Mark H G Verheijen and Danielle Posthuma

    Abstract
    Tourette syndrome is a heritable neurodevelopmental disorder whose pathophysiology remains unknown. Recent genome-wide association studies suggest that it is a polygenic disorder influenced by many genes of small effect. We tested whether these genes cluster in cellular function by applying gene-set analysis using expert curated sets of brain-expressed genes in the current largest available Tourette syndrome genome-wide association data set, involving 1285 cases and 4964 controls. The gene sets included specific synaptic, astrocytic, oligodendrocyte and microglial functions. We report association of Tourette syndrome with a set of genes involved in astrocyte function, specifically in astrocyte carbohydrate metabolism. This association is driven primarily by a subset of 33 genes involved in glycolysis and glutamate metabolism through which astrocytes support synaptic function. Our results indicate for the first time that the process of astrocyte-neuron metabolic coupling may be an important contributor to Tourette syndrome pathogenesis.

  2. #2

    Default Re: Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis

    Does anyone have any idea what this means in lay terms?

  3. #3
    Join Date
    Apr 2005
    Location
    Ottawa, Canada
    Posts
    5,941

    Default Re: Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis

    JAG,

    Thanks for asking the question!

    Perhaps one of the medical professionals who monitor our Forum could elaborate on the significance of these findings.

    My own lay person's interpretation of these findings, and I stand to be corrected, is that science is discovering a higher degree of complexity in the way information is transmitted within the brain's synapses (circuitry).

    Our results indicate for the first time that the process of astrocyte-neuron metabolic coupling may be an important contributor to Tourette syndrome pathogenesis.
    This article may be relevant:

    Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

    I don't know if these findings would have an immediate direct effect on how we manage Tourette symptoms, but may have an impact on how scientists gain a better understanding on the mechanism of Tourette Syndrome within the brain.

    It would be great to have someone with a scientific understanding of this article provide their insights!

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •