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Thread: Study: TS Tics Vanish With Histamine

  1. #1
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    Default Study: TS Tics Vanish With Histamine

    Tourette-like tics vanish in mice treated with histamine
    Yale News
    June 5, 2017

    The activity of neurons in the striatum are regulated by neurotransmitter histamine and is associated with Tourette-like grooming behavior in mice

    Yale scientists produced increased grooming behavior in mice that may model tics in Tourette syndrome and discovered these behaviors vanish when histamine — a neurotransmitter most commonly associated with allergies — is introduced into their brains.

    The research, published the week of June 5 in the Proceedings of the National Academy of Sciences, reaffirms previous genetic studies that linked histamine production and Tourette, an often serious neuropsychological disorder marked by motor and vocal tics.

    “The intriguing thing is we were able to reverse this behavior in adult mice,” said Chris Pittenger, associate professor of psychiatry and senior author of the study. ”It is easier to imagine how this insight might develop into a treatment than if the abnormalities arose during early development.”

    The researchers were able to trigger excessive grooming in mice by shutting down histamine neurons projecting to the basal ganglia, an area of the brain previously linked to Tourette. They could reverse the behavior by reintroducing histamine directly into the striatum, confirming that this structure is a central contributor to the pathology.

    Histamine’s role in immunological reactions such as allergies has been intensively studied, but in recent years the neurotransmitter histamine in the brain has been linked to a variety of conditions, such as Parkinson’s, multiple sclerosis, autism and obsessive compulsive disorder, as well as Tourette syndrome.

    Primary funding for the study was provided by the National Institutes of Health and the Allison Family Foundation.



    Source article Proceedings of the National Academy of Sciences PDF :acrobat of abstract attached

  2. #2
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    Default Re: Study: TS Tics Vanish With Histamine

    Quote Originally Posted by Steve View Post
    Tourette-like tics vanish in mice treated with histamine


    “The intriguing thing is we were able to reverse this behavior in adult mice,” said Chris Pittenger, associate professor of psychiatry and senior author of the study. ”It is easier to imagine how this insight might develop into a treatment than if the abnormalities arose during early development.”
    Thanks for the interesting post Steve. Gave me a chance to read up on Histamine. My only knowledge of it was the runny nose and itchy eyes reaction.
    After reading the articles and the Wikipedia page on histamine and the different types of receptors I'm guessing it's the H2 receptors that are in question here:

    Histamine H2 receptor:

    LOCATION:
    CNS: Dorsal striatum (caudate nucleus and putamen), cerebral cortex (external layers), hippocampal formation, dentate nucleus of the cerebellum

    FUNCTION:
    CNS: Not established (note: most known H2 receptor ligands are unable to cross the blood–brain barrier in sufficient concentrations to allow for neuropsychological and behavioral testing)"
    ------------------------------------------------

    The FUNCTION description makes getting Histamine to H2 receptors that would pass the blood-brain barrier quite a barrier (no pun intended) to overcome.
    All in all the link between CNS disorders and histamine seems like a great discovery but there's a big obstacle to overcome before any type of treatment would be possible...
    Just my little 2 cents Canadian or 1.5 cents US
    Gary
    "If at first you don't succeed....
    CRY and CRY again!"

  3. #3
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    Default Re: Study: TS Tics Vanish With Histamine

    Gary,

    The study of histamine in connection with Tourette has been an area of interest to TS investigators for about three years now. If you do a Forum search using the term "histamine", you'll see the progression of articles and studies over the years.

  4. #4
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    Default Re: Study: TS Tics Vanish With Histamine

    Quote Originally Posted by Steve View Post
    Gary,

    The study of histamine in connection with Tourette has been an area of interest to TS investigators for about three years now. If you do a Forum search using the term "histamine", you'll see the progression of articles and studies over the years.
    Thanks Steve, never crossed my mind to search the forum. Will definitely have a scan when I get a chance
    Gary
    "If at first you don't succeed....
    CRY and CRY again!"

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